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ORIGINAL ARTICLE
Year : 2017  |  Volume : 6  |  Issue : 1  |  Page : 17-20

Immunohistochemical expression of SOX11 as a diagnostic tool for mantle cell lymphoma


Department of Pathology and Forensic Medicine, College of Medicine, AL-Nahrain University, Baghdad, Iraq

Correspondence Address:
Bassam M Hameed
Department of Pathology and Forensic Medicine, College of Medicine, AL-Nahrain University, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijh.ijh_8_17

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Background: SOX11 is a transcription factor that has role in central nervous system development, it has found that this marker expressed in nuclei of mantle cell lymphoma and may play vital role in diagnosis and pathogenesis of mantle cell lymphoma. AIMS: To evaluate the diagnostic role of SOX11 immunohistochemical expression in mantle cell lymphoma. Materials and Methods: A cross sectional study was designed, a total of 62 left over tissue samples (paraffin block of bone marrow biopsy) were included in the study. All the samples were taken from the Medical city/ teaching laboratories, and presented during the period 2014-2016. Cases diagnosed according to the WHO classification of mature B-cell Neoplasms with 26 cases having CLL/SLL, 17 were mantle cell lymphoma and 19 cases with follicular lymphoma. All the practical steps were carried out in teaching laboratories department of pathology and forensic medicine/ Al-Nahrain University - Collage Of Medicine. From each block, two sections were taken, and one were immunohistochemically stained for SOX11. And other section stained for haemtotoxylin and eosin stain. Results: In MCL, nuclear staining of SOX11 was seen in 16 (94.12%) of 17 patients, SOX11 nuclear staining was also seen in 1 case (3.85%) of 26 CLL/SLL cases, and 0 (0.0%) of 19 patients with FL. Furthermore, compared with CLL/SLL and FL, the positive rate of SOX11 nuclear staining was significantly higher in the MCL samples (P < 0.001). In addition SOX11 nuclear positivity had high sensitivity (94.12%) and specificity (97.78 %) in diagnosis of MCL compared to Cyclin D1. Conclusions: SOX11 is a powerful diagnostic tool for MCL, and may help in distinguishing it from other B-cell lymphoproliferative disoreders.


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