Year : 2019 | Volume
: 8 | Issue : 1 | Page : 14--20
Clinicopathological, immunohistochemical charachtaristic and the outcome of Hodghkin lymphoma patients in Erbil city, Iraq
Lilan Bahzad Mohammedzaki1, Kawa Muhammedamin Hasan1, Ranan Kardagh Polus2, Ahmed Khudair Yassin1
1 Department of Clinical Hematology, Nanakali Hospital for Blood Diseases and Cancer, Irbil, Iraq
2 Department of Pathology, Collage Medicine, HMU, Irbil, Iraq
BACKGROUND: Hodgkin lymphoma (HL) has unique epidemiological features with diversified pathologies and exhibits considerable clinicopathological variations in different parts of the world.
OBJECTIVES: We aimed in this study to assess clinic-pathological features, immunohistochemistry and outcome of HL patients treated in Erbil, northren Iraq.
PATIENTS AND METHODS: This was a retrospective study conducted in Nanakaly Hospital for blood diseases and oncology in Erbil, North Iraq; a total of 125 patients diagnosed between January 2012 and December 2016 were involved; they were assessed for their clinical characteristics and histopathology and immunophenotyping findings and their outcome was evaluated as well.
RESULTS: The median age was 28 years (range: 18–71 years); 55% were male and 41% had Stage II disease; common histological type is nodular sclerosis (51.2%) followed by mixed cellularity (43.2%); CD30 was positive in nearly all cases of classical HL, and CD15 was positive in 98.7% and CD20 was positive in 75% in nodular lymphocyte predominant subtype. Most of the patients received adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy, and the 5-year overall survival in our study is 70%. Advanced stage (IV), high lactate dehydrogenase level, low hemoglobin, and splenomegaly are significant predictors for poor survival.
CONCLUSION: Our patient exhibited outcomes that were lower to those reported in developed countries.
Dr. Lilan Bahzad Mohammedzaki
Nanakali Hospital for Blood Diseases and Cancer, Irbil
|How to cite this article:|
Mohammedzaki LB, Hasan KM, Polus RK, Yassin AK. Clinicopathological, immunohistochemical charachtaristic and the outcome of Hodghkin lymphoma patients in Erbil city, Iraq.Iraqi J Hematol 2019;8:14-20
|How to cite this URL:|
Mohammedzaki LB, Hasan KM, Polus RK, Yassin AK. Clinicopathological, immunohistochemical charachtaristic and the outcome of Hodghkin lymphoma patients in Erbil city, Iraq. Iraqi J Hematol [serial online] 2019 [cited 2019 Dec 6 ];8:14-20
Available from: http://www.ijhonline.org/article.asp?issn=2072-8069;year=2019;volume=8;issue=1;spage=14;epage=20;aulast=Mohammedzaki;type=0