Close
  Indian J Med Microbiol
 

Figure 2: Mechanisms of BRAF inhibitor resistance. RAF isoform switching, activation of receptor tyrosine kinases such as insulin-like growth factor-1 receptor and engagement of the PI3K pathway to promote cell survival. PTEN loss leads to activation of the PI3K pathway

Figure 2: Mechanisms of BRAF inhibitor resistance. RAF isoform switching, activation of receptor tyrosine kinases such as insulin-like growth factor-1 receptor and engagement of the PI3K pathway to promote cell survival. PTEN loss leads to activation of the PI3K pathway