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  Indian J Med Microbiol
 

Figure 3: Mechanism of action of imatinib in chronic myelogenous leukemia, (a)It binds to the amino acids of the BCR/ABL tyrosine kinase adenosine triphosphate binding site and stabilizes the inactive, nonadenosine triphosphate binding form of BCR/ABL. (b) How imatinib preventing tyrosine autophosphorylation and, in turn, phosphorylation of its substrates

Figure 3: Mechanism of action of imatinib in chronic myelogenous leukemia, (a)It binds to the amino acids of the BCR/ABL tyrosine kinase adenosine triphosphate binding site and stabilizes the inactive, nonadenosine triphosphate binding form of BCR/ABL. (b) How imatinib preventing tyrosine autophosphorylation and, in turn, phosphorylation of its substrates