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Year : 2014  |  Volume : 3  |  Issue : 2  |  Page : 108-115

Lipid Profile in Iraqi Children with ί-thalassemia Major

1 bacteriology unit, National center of hematology/ Almustansiriya University
2 Aphresis unit, National center of hematology/ Almustansiriya University
3 National Diabetes Center / Almustansiriya University

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Background: Thalassemia are group of genetic disorders in which production of normal hemoglobin (Hb) is partly or completely suppressed because of defective synthesis of one or more globin chains, vary from asymptomatic forms to severe or even fatal entities . People with thalassemia make less hemoglobin which results in mild or severe anemia present as microcytic anemia. thalassemias are classified according to which chain of the hemoglobin molecule is affected. In α thalassemias, α globin chain is affected, while in β thalassemia, production of the β globin chain is affected. Lipid abnormalities have been detected in different types of beta thalassemia, suggested mechanisms including plasma dilution due to anemia, accelerated erythropoiesis resulting in increased cholesterol uptake by macrophages and histiocytes of the reticuloen-dothelial system, defective liver functioning due to iron overload, macrophage system activation with cytokine release, and hormonal disturbances, Objectives : The purpose of the study was to examine the blood lipid profile in children with beta-Thalassemia major in Iraq , and to determine the factors that affect it. Material and Method: Blood lipid profiles of forty-five patients between the ages of three and ten years with beta-Thalassemia major who were receiving regular chelation therapy followed by from paediatric clinic of Ibn-albalady hospital were examined retrospectively. Blood lipid profiles of thirty healthy children were taken for use as the control group. Results: Hb and Hct values of the group with Beta-Thalassemia major were significantly lower than the control group . Ferritin values in the group with Beta-Thalassemia major were found to be significantly higher than in the control group . Cholesterol, HDL-cholesterol, LDL-cholesterol levels were found to be significantly lower in patients with Beta- Thalassemia major than in the control group , while the triglyceride level was found to be higher . Conclusion: lower total cholesterol, LDL-HDLcholesterol and high TG was found in BTM groups compared to healthy control participants. The suggested mechanisms for the decreases in lipids are increased erythropoiesis and cholesterol consumption, iron overload, hormonal change and oxidative stress in BTM.

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