Source of Support: None, Conflict of Interest: None
Background: Non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferative malignancies with different patterns of behavior and responses to treatment. The understanding and histopathological diagnosis of NHL has improved with the use of advanced technology. The immunophenotyping of tumors of hematopoietic origin serves in the first place to distinguish these neoplasms from others, and to distinguish neoplasms from reactive processes.
Objectives : The aim of this study was to determine the percent of each category of NHL
Patients and Methods : Sixty eight patients who were diagnosed to have stage 4 non-Hodgkin lymphoma by histopathological examination of bone marrow aspirate and biopsy at National Center of Hematology/Baghdad were subjected to immunohistochemistry examination, two cases diagnosed as hairy cell leukemia by histopathological examination but not by immunohistochemistry as there were no CD markers available at the time of study so they were discarded from this study. Immunohistochemistry was done either in hospital or in private laboratory for proper subtyping of the disease and yet to receive correct therapy and better response.
Results : Cases were diagnosed as fallows
B-cell lymphoma constitute 57 cases 86.36% T-cell non-hodgkin lymphoma 6 cases 9.09% Splenic lymphoma 1 case 1.5% Mantle cell lymphoma 2 cases 3.03%
Conclusion: Immunohistochemical study is a specific method to aid histopathology in proper diagnosis and subtyping of non-Hodgkin lymphoma