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Year : 2014  |  Volume : 3  |  Issue : 2  |  Page : 98-107

Cutaneous manifestation among patients with β- thalassemia major

1 Ministry of Health, Directorate of Health, Erbil, Iraq
2 Department of Internal Medicine, College of Medicine, Hawler Medical University, Erbil, Iraq

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Background: Dermatological manifestations among β thalassemia major patients including skin changes as well as nail, hair, oral mucosa changes and leg ulcer were reported among these patients, either due to the hemolytic process of the disease itself or as a sequel of therapeutic effect taxes of blood transfusion and iron overload complication. In Kurdistan there is no study has yet investigated the common dermatologic problems that coexist with β-thalassemia major. Objectives : The purpose of this study was to determine the commonly seen dermatologic problems in patients with β-thalassemia major. Patients and Method: A descriptive cross sectional study performed at Erbil Thalassemia center, the study was conducted among 176 patients over a period extended from April, 2013 to January, 2014. They were assessed for cutaneous manifestation with clinical importance of static laboratory tests. Results: All patients enrolled in this study had at least one cutaneous manifestation. The disorders are in decreasing order of frequency was pallor, xerosis, jaundice, bronze skin, hyperpigmentation and the least frequent was vitiligo. Most of the of the findings (31.8%) were between (10-15) years age group. The mean age of patients, the mean duration of blood transfusion and the mean of serum ferritin level among patients with xerosis, pallor, hyperpigmentation and jaunduce was higher and was statistically significant (p<0.05) also there was a significant association between HCV positive and patients with xerosis, hyperpigmentation and jaundice (p<0.05). Conclusion: The cutaneous disorders are common among beta thalasemia patients, pallor ,xerosis and jaundice were the common skin changes, while white streak (leukonychia)and gingivitis are the most common nail and oral mucoasa changes respectivly. Xerosis is common in patients recieving desferoxamine, serum ferritin level was higher in patients with xerosis,hyperpigmentation and jaundice.

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