| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 9
| Issue : 2 | Page : 113-117 |
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Seasonality in acute promyelocytic leukemia: Fact or myth?
Amer Shareef Mohammed1, Talib Hassan Ali2, Alaa Fadil Alwan3
1 Department of Internal Medicine, College of Medicine, University of Thiqar, Thiqar, Iraq
2 Department of Microbiology, College of Medicine, University of Thiqar, Thiqar, Iraq
3 Consultant hematologist, The national center of Hematology, Baghdad, Iraq
Correspondence Address:
Dr. Amer Shareef Mohammed
Department of Internal Medicine, College of Medicine, University of Thiqar, Thiqar
Iraq
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijh.ijh_27_20
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BACKGROUND: Acute promyelocytic leukemia (APL) is a biologically and clinically distinct subtype of acute myeloid leukemia (AML) Etiological and seasonal factors that play a role in APL still unclear.
OBJECTIVES: The aim of the study was to retrospectively evaluate the available data to assess the impact of seasonal variations on incidence of APL over a period of 6 years.
PATIENTS AND METHODS: A retrospective, observational study based on APL record of a Hematology Nasiriyah Center from January 2014 to January 2020 was processed. The collected data of diagnosed (APL) patients at this center for 6 years was analyzed, and APL presenting in each month of the year was also assessed for any evidence of seasonality.
RESULTS: Fifty-eight cases of APL were included in this study: there were 22 males (37.93%) and 36 females (62.07%). The mean age was 31.1 ± 14.4 years (minimum 15 and maximum 67). We found a pronounced peak of APL occurrence in March (within winter and early spring months) and decline in summer to zero point in August, which was repeated periodical all studied 6 years.
CONCLUSIONS: Seasonal pattern of APL was observed. Investigation of specific seasonal risk factors would be informative in explaining the etiology behind the observed variation.
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