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Year : 2020  |  Volume : 9  |  Issue : 2  |  Page : 113-117

Seasonality in acute promyelocytic leukemia: Fact or myth?

1 Department of Internal Medicine, College of Medicine, University of Thiqar, Thiqar, Iraq
2 Department of Microbiology, College of Medicine, University of Thiqar, Thiqar, Iraq
3 Consultant hematologist, The national center of Hematology, Baghdad, Iraq

Correspondence Address:
Dr. Amer Shareef Mohammed
Department of Internal Medicine, College of Medicine, University of Thiqar, Thiqar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijh.ijh_27_20

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BACKGROUND: Acute promyelocytic leukemia (APL) is a biologically and clinically distinct subtype of acute myeloid leukemia (AML) Etiological and seasonal factors that play a role in APL still unclear. OBJECTIVES: The aim of the study was to retrospectively evaluate the available data to assess the impact of seasonal variations on incidence of APL over a period of 6 years. PATIENTS AND METHODS: A retrospective, observational study based on APL record of a Hematology Nasiriyah Center from January 2014 to January 2020 was processed. The collected data of diagnosed (APL) patients at this center for 6 years was analyzed, and APL presenting in each month of the year was also assessed for any evidence of seasonality. RESULTS: Fifty-eight cases of APL were included in this study: there were 22 males (37.93%) and 36 females (62.07%). The mean age was 31.1 ± 14.4 years (minimum 15 and maximum 67). We found a pronounced peak of APL occurrence in March (within winter and early spring months) and decline in summer to zero point in August, which was repeated periodical all studied 6 years. CONCLUSIONS: Seasonal pattern of APL was observed. Investigation of specific seasonal risk factors would be informative in explaining the etiology behind the observed variation.

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