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Year : 2022  |  Volume : 11  |  Issue : 2  |  Page : 182-185

Addison's disease in a lady with hemoglobin H disease

Hiwa Hemato-Oncology Hospital-Iraq-Kurdistan Region-Slemani, Kurdistan Higher Council of Medical Specialties, Sulaymaniyah, Iraq

Correspondence Address:
Dr. Nawshirwan Gafoor Rashid
Hiwa Hemato-Oncology Hispital, Iraq-KRI-Slemani
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijh.ijh_42_22

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Hemoglobin H (HbH) disease is alpha (α)-thalassemia characterized by the inactivation of three of four α-globin genes due to deletions with or without nondeletional α-thalassemia. HbH disease is not necessarily a benign disorder as has been generally thought. Here, we report a 33-year-old female who has a lifelong history of anemia without blood transfusions. but when she got married, during pregnancies developed symptomatic moderate-to-severe anemia necessitating infrequent blood transfusions. Later due to symptomatic anemias and increasing the frequency of blood transfusions, she underwent splenectomy, 3 years from splenectomy she developed a gradual dark skin discoloration with frequent hypotension and was diagnosed with Addison's disease which is a rare endocrine complication of thalassemia-induced iron overload.

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