Iraqi Journal of Hematology

LETTER TO EDITOR
Year
: 2018  |  Volume : 7  |  Issue : 2  |  Page : 97--98

Human genetic factors associated with protection against malaria


Bashir Abdrhman Bashir Mohammed, Mohammed Omer Gibreel 
 Department of Hematology, Division of Medical Laboratory Sciences, Port Sudan Ahlia College, Port Sudan, Sudan

Correspondence Address:
Dr. Bashir Abdrhman Bashir Mohammed
Department of Hematology, Division of Medical Laboratory Sciences, Port Sudan Ahlia College, Port Sudan
Sudan




How to cite this article:
Bashir Mohammed BA, Gibreel MO. Human genetic factors associated with protection against malaria.Iraqi J Hematol 2018;7:97-98


How to cite this URL:
Bashir Mohammed BA, Gibreel MO. Human genetic factors associated with protection against malaria. Iraqi J Hematol [serial online] 2018 [cited 2022 Oct 6 ];7:97-98
Available from: https://www.ijhonline.org/text.asp?2018/7/2/97/239529


Full Text

Dear Editor,

Today, the knowledge that specific genetic factor variants may contribute to disease resistance in human is becoming well documented.[1] Human genetic factors shield against the malaria point to inherited changes in the deoxyribonucleic acid of human erythrocytes which increase resistance to the disease and eventually increase survival time of the host to genetic change as well as the protection of erythrocytes from invasion by Plasmodium parasites or replications within the red cells. These genetic factors (alterations) are most commonly linked to molecules fundamental to erythrocyte function such as enzymes, cytoskeletal proteins, and hemoglobin (Hb) of red cells.[2] Individuals with ovalocytosis (elliptocytosis) have scanty parasitemia of Plasmodium vivax and Plasmodium falciparum because the elliptical form of erythrocyte resists parasitic invasion (mutation in the gene encoding Band 3 protein).[3] Red blood cell of individuals that lack the Duffy blood group antigens Fya and Fyb also gives a protection and particularly sustained only to homozygotes. These glycophorin protein receptors are needed to P. vivax and Plasmodium knowlesi to attach and invade the erythrocyte.[4]Plasmodium parasites did not grow well in erythrocytes that contain high percentage of Hb peptides α2γ2 (HbF). Accordingly, the newborn babies have protection against malaria parasites, especially the first few months of life.[5] Individuals with certain polymorphisms of human leukocyte antigen (HLA) are also considered to protect against malaria, such as HLA Class I antigen (HLA Bw53) and HLA Class II haplotype (DRB1*13OZ-DQB1*0501). Furthermore, HLA correlations vary depending on the genetic constitution of the polymorphic Plasmodium parasites, which change depending on the geographical area.[6] In addition, individuals with sickle cell trait (HbAS) are also protected against the severity of the falciparum malaria (due to changed display of P. falciparum erythrocyte membrane protein 1, which is the parasitic major cytoadherence legend and virulence factor on the erythrocyte surface.[7] Furthermore, homozygous Hb C individuals (CC) express a very high protection against malaria in the time that heterozygous (AC) express moderate protection as that seen in glucose-6-phosphate dehydrogenase deficiency (due to the red cell's inability to restore nicotinamide adenine dinucleotide phosphate hydrogen and glutathione, the parasite may be more untenable to the reaction when the parasite breaks down Hb).[9] The degree of parasitemia is lower because the red cells in these conditions are released by the spleen before the parasite is progressed into schizont.[9] Moreover, β (beta)-thalassemia trait also observed to protect against falciparum malaria infection.[10] HbE(β26 Glu → Lys) variant has been present in approximately 70% in South Asia. It also makes the majority of red cells relatively resistant to be invaded by falciparum malaria. This would not shield from uncomplicated malaria infection but may inhibit the development of heavy parasitemia.[11] The severity of pyruvate kinase deficiency and scope of protection against malaria are significantly correlated.[12] The Gerbich (Ge) antigen system is an integrative erythrocyte membrane protein and plays an important functional role in maintaining the red blood cell shape. It also acts as the ligand for the P. falciparum erythrocyte-binding protein. Individuals with Ge negativity (rare) are relatively less susceptible to invasion by P. falciparum. Such persons have a condition such as elliptocytosis which characterized by an oval- or elliptical-shaped erythrocytes.[13] Rarely, mutations of glycophorin A and B proteins are also known to interpose resistance to P. falciparum.[14]

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Conflicts of interest

There are no conflicts of interest.

References

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