Iraqi Journal of Hematology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 9  |  Issue : 2  |  Page : 123--126

Soluble P- and E-selectin levels as determinants of vaso-occlusive crises among sickle cell anemia patients in a tertiary hospital Northwestern Nigeria


Sani Awwalu1, Abdulaziz Hassan1, Aisha Indo Mamman1, Abdul Wahab Alhassan2, Ismaila Nda Ibrahim1, Ibrahim Usman Kusfa1, Aliyu Dahiru Waziri1 
1 Department of Haematology and Blood Transfusion, Ahmadu Bello University Teaching Hospital Zaria, Kaduna State, Nigeria
2 Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Ahmadu Bello University Zaria, Kaduna State, Nigeria

Correspondence Address:
Dr. Sani Awwalu
Department of Haematology and Blood Transfusion, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State
Nigeria

BACKGROUND: Vascular E- and P-selectins play important roles in sickle cell anemia (SCA), vaso-occlusive crises (VOC); however, the extent to which they determine VOC has not been studied. OBJECTIVES: The aims of the study were to assess vascular selectin levels and the extent to which they determine VOC among SCA patients. SUBJECTS AND METHODS: This was a cross-sectional comparative study conducted among patients with SCA in a tertiary hospital, Northwestern Nigeria. Eighty-eight participants were enrolled (44 each in VOC and steady state). Soluble E (sE) and P (sP) selectin levels were assessed using enzyme-linked immunosorbent assay technique. The frequency of blood transfusion and bone pains was collated. RESULTS: Patients with VOC compared to those in steady state had higher levels of sP-selectin (5.5 ± 4.6 ng/ml vs. 3.2 ± 0.8 ng/ml, P = 0.001) and mean rank sE-selectin (53.2 vs. 35.8, P = 0.001). The odds ratio (OR) for sE-selectin levels and VOC was 1.135 (P = 0.009), while that of sP-selectin was 2.693 (P = 0.002). The adjusted ORs for sE-selectin and sP-selectin were 1.184 (95% confidence interval [CI]: 1.021, 1.373) and 3.748 (95% CI: 1.475, 9.524), respectively. CONCLUSIONS: Patients in VOC have elevated sP-and E-selectin levels. sP-selectin level is a better predictor of VOC compared to sE-selectin.


How to cite this article:
Awwalu S, Hassan A, Mamman AI, Alhassan AW, Ibrahim IN, Kusfa IU, Waziri AD. Soluble P- and E-selectin levels as determinants of vaso-occlusive crises among sickle cell anemia patients in a tertiary hospital Northwestern Nigeria.Iraqi J Hematol 2020;9:123-126


How to cite this URL:
Awwalu S, Hassan A, Mamman AI, Alhassan AW, Ibrahim IN, Kusfa IU, Waziri AD. Soluble P- and E-selectin levels as determinants of vaso-occlusive crises among sickle cell anemia patients in a tertiary hospital Northwestern Nigeria. Iraqi J Hematol [serial online] 2020 [cited 2021 Jan 16 ];9:123-126
Available from: https://www.ijhonline.org/article.asp?issn=2072-8069;year=2020;volume=9;issue=2;spage=123;epage=126;aulast=Awwalu;type=0