Year : 2020 | Volume
: 9 | Issue : 2 | Page : 61--65
Growth-differentiation factor-15 expression in anemia of chronic disease and iron-deficiency anemia
Noor Sabeeh Abdullah1, Abeer Anwer Ahmed2
1 Department of Hematology, Al-Yarmouk Teaching Hospital, Baghdad, Iraq
2 Department of Pathology, College of Medicine, Mustansiriyah University, Baghdad, Iraq
BACKGROUND: Iron-deficiency anemia (IDA) is a common hematological disorder. Anemia of chronic disease (ACD) is mild-to-moderately severe anemia associated with chronic diseases. Growth-differentiation factor-15 (GDF-15) is a member of the transforming growth factor-β, produced by late-stage erythroid precursors in the bone marrow; it suppresses hepcidin expression during ineffective erythropoiesis. The aim of this study was to measure the level of the GDF-15 level in ACD and IDA and to evaluate its ability to differentiate between ACD and ACD with coexisting iron deficiency (mixed anemia).
PATIENTS, MATERIALS AND METHODS: The present study including 87 persons “30 with IDA, 30 with ACD, and 27 controls.” The following investigations were done: complete blood count, erythrocyte sedimentation rate, iron profile (serum iron and total iron-binding capacity), C-reactive protein, ferritin, hepcidin, and GDF-15, depending on the results of these investigations, some patients of ACD group appear to be ACD with co-existing iron deficiency. The analysis of data was carried out using the Statistical Packages for the Social Sciences software version 24.
RESULTS: The serum hepcidin was significantly lower in IDA, whereas the serum GDF-15 is comparable to that of the control group. The serum hepcidin and serum GDF-15 were significantly higher in (ACD and mixed anemia) group compared to the control group.
CONCLUSION: GDF-15 is high in ACD group and comparable to the control in iron-deficiency group, and it is not a useful marker to differentiate between ACD and ACD with coexisting iron deficiency.
Dr. Noor Sabeeh Abdullah
Department of Laboratory, Al-Yarmouk Teaching Hospital, Baghdad
|How to cite this article:|
Abdullah NS, Ahmed AA. Growth-differentiation factor-15 expression in anemia of chronic disease and iron-deficiency anemia.Iraqi J Hematol 2020;9:61-65
|How to cite this URL:|
Abdullah NS, Ahmed AA. Growth-differentiation factor-15 expression in anemia of chronic disease and iron-deficiency anemia. Iraqi J Hematol [serial online] 2020 [cited 2021 Apr 19 ];9:61-65
Available from: https://www.ijhonline.org/article.asp?issn=2072-8069;year=2020;volume=9;issue=2;spage=61;epage=65;aulast=Abdullah;type=0